United States securities and exchange commission logo August 18, 2022 Henry Ji Chairman of the Board, CEO and President Sorrento Therapeutics, Inc. 4955 Directors Place San Diego, CA 92121 Re: Sorrento Therapeutics, Inc. Form 10-K for the year ended December 31, 2021 Filed March 11, 2022 Form 10-Q for the period ended March 31, 2022 Filed May 5, 2022 Form 10-Q for the period ended June 30, 2022 Filed August 15, 2022 File No. 001-36150 Dear Dr. Ji: We have limited our review of your filings to the financial statements and related disclosures and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to the comment within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to the comment, we may have additional comments. Form 10-Q for the period ended June 30, 2022 Notes to Unaudited Consolidated Financial Statements 7. Debt, page 15 1. Please provide us with your accounting basis, citing relevant authoritative literature, to account for the Consent Under and Amendment No. 4 to your Indenture agreement as a troubled debt restructuring rather than a modification or extinguishment. In closing, we remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Henry Ji Sorrento Therapeutics, Inc. August 18, 2022 Page 2 You may contact Sasha Parikh at 202-551-3627 or Daniel Gordon at 202-551-3486 with any questions. FirstName LastNameHenry Ji Sincerely, Comapany NameSorrento Therapeutics, Inc. Division of Corporation Finance August 18, 2022 Page 2 Office of Life Sciences FirstName LastName