United States securities and exchange commission logo July 25, 2022 Henry Ji Chairman of the Board, CEO and President Sorrento Therapeutics, Inc. 4955 Directors Place San Diego, CA 92121 Re: Sorrento Therapeutics, Inc. Form 10-K for the year ended December 31, 2021 Filed March 11, 2022 Form 10-Q for the period ended March 31, 2022 Filed May 5, 2022 File No. 001-36150 Dear Dr. Ji: We have limited our review of your filing to the financial statements and related disclosures and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to these comments within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comments apply to your facts and circumstances, please tell us why in your response. After reviewing your response to these comments, we may have additional comments. Form 10-K for the year ended December 31, 2021 Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations Results of Operations Comparison of the Years Ended December 31, 2021 and 2020, page 77 1. Please quantify each of the factors you noted for the selling, general and administrative expenses line item that explains the increase and/or decrease from the current period to the respective prior period, as applicable. For example, you disclosed that selling, general and administrative expenses for your Sorrento Therapeutics segment increased as compared to the prior fiscal year and were primarily attributed to higher headcount, professional fees and stock-based compensation expense as compared to the same period of the prior year. Please quantify each of the factors noted. Henry Ji Sorrento Therapeutics, Inc. July 25, 2022 Page 2 2. You disclosed that research and development expenses for your Sorrento Therapeutics segment increased by $96.3 million as compared to the prior fiscal year and were primarily driven by higher headcount and increased clinical development costs spent on advancing your various research and development programs. As research and development expenses constitute your most significant expense in the periods presented, please provide us proposed disclosure to be provided in future filings the costs incurred during each period presented for each of your key research and development projects. If you do not track your research and development costs by project, please disclose that fact and explain why you do not maintain and evaluate research and development costs by project. Provide other quantitative or qualitative disclosure that provides more transparency as to the type of research and development expenses incurred (i.e. by nature or type of expense) which should reconcile to total research and development expense on the Statements of Operations. Form 10-Q for the period ended March 31, 2022 Item 4. Controls and Procedures Evaluation of Disclosure Controls and Procedures, page 25 3. We noted that you did not state management's conclusion with regards to the effectiveness of your disclosure controls and procedures as of the end of March 31, 2022. As required by Item 307 of Regulation S-K, please disclose management's conclusion with regards to the effectiveness of your disclosure controls and procedures in future filings. In closing, we remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. You may contact Sasha Parikh at 202-551-3627 or Daniel Gordon at 202-551-3486 with any questions. FirstName LastNameHenry Ji Sincerely, Comapany NameSorrento Therapeutics, Inc. Division of Corporation Finance July 25, 2022 Page 2 Office of Life Sciences FirstName LastName