United States securities and exchange commission logo





                              July 25, 2022

       Henry Ji
       Chairman of the Board, CEO and President
       Sorrento Therapeutics, Inc.
       4955 Directors Place
       San Diego, CA 92121

                                                        Re: Sorrento
Therapeutics, Inc.
                                                            Form 10-K for the
year ended December 31, 2021
                                                            Filed March 11,
2022
                                                            Form 10-Q for the
period ended March 31, 2022
                                                            Filed May 5, 2022
                                                            File No. 001-36150

       Dear Dr. Ji:

              We have limited our review of your filing to the financial
statements and related
       disclosures and have the following comments. In some of our comments, we
may ask you to
       provide us with information so we may better understand your disclosure.

              Please respond to these comments within ten business days by
providing the requested
       information or advise us as soon as possible when you will respond. If
you do not believe our
       comments apply to your facts and circumstances, please tell us why in
your response.

                                                        After reviewing your
response to these comments, we may have additional comments.

       Form 10-K for the year ended December 31, 2021

       Item 7. Management's Discussion and Analysis of Financial Condition and
Results of Operations
       Results of Operations
       Comparison of the Years Ended December 31, 2021 and 2020, page 77

   1.                                                   Please quantify each of
the factors you noted for the selling, general and administrative
                                                        expenses line item that
explains the increase and/or decrease from the current period to the
                                                        respective prior
period, as applicable. For example, you disclosed that selling, general and
                                                        administrative expenses
for your Sorrento Therapeutics segment increased as compared to
                                                        the prior fiscal year
and were primarily attributed to higher headcount, professional fees
                                                        and stock-based
compensation expense as compared to the same period of the prior year.
                                                        Please quantify each of
the factors noted.
 Henry Ji
Sorrento Therapeutics, Inc.
July 25, 2022
Page 2
2.       You disclosed that research and development expenses for your Sorrento
Therapeutics
         segment increased by $96.3 million as compared to the prior fiscal
year and were
         primarily driven by higher headcount and increased clinical
development costs spent on
         advancing your various research and development programs. As research
and
         development expenses constitute your most significant expense in the
periods presented,
         please provide us proposed disclosure to be provided in future filings
the costs incurred
         during each period presented for each of your key research and
development projects. If
         you do not track your research and development costs by project,
please disclose that fact
         and explain why you do not maintain and evaluate research and
development costs by
         project. Provide other quantitative or qualitative disclosure that
provides more
         transparency as to the type of research and development expenses
incurred (i.e. by nature
         or type of expense) which should reconcile to total research and
development expense on
         the Statements of Operations.
Form 10-Q for the period ended March 31, 2022

Item 4. Controls and Procedures
Evaluation of Disclosure Controls and Procedures, page 25

3.       We noted that you did not state management's conclusion with regards
to the effectiveness
         of your disclosure controls and procedures as of the end of March 31,
2022. As required
         by Item 307 of Regulation S-K, please disclose management's conclusion
with regards to
         the effectiveness of your disclosure controls and procedures in future
filings.
       In closing, we remind you that the company and its management are
responsible for the
accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
absence of action by the staff.

       You may contact Sasha Parikh at 202-551-3627 or Daniel Gordon at
202-551-3486 with
any questions.



FirstName LastNameHenry Ji                                    Sincerely,
Comapany NameSorrento Therapeutics, Inc.
                                                              Division of
Corporation Finance
July 25, 2022 Page 2                                          Office of Life
Sciences
FirstName LastName