Sorrento Announces Its Lead Protein-Based COVID-19 Vaccine Candidate – DYAI-100 – Elicits Strong Neutralizing Immune Responses in Vaccinated Animals Against SARS-CoV-2 and Multiple Major Variants of Concern
- Immunization with a protein-based immunogen, DYAI-100, a receptor binding domain (RBD) of SARS-CoV-2, resulted in potent B cell immunity in preclinical studies, with strong serological recognition of the original SARS-CoV-2 virus and major variants of concern (Alpha, Beta, Gamma, and Delta; “VOCs”).
- The sera of vaccinated mice demonstrated potent neutralization of viral infection by the original SARS-COV-2 and major VoCs, such as Beta and Delta, and to a lesser extent Gamma in vitro in a live virus challenge Vero-E6 cell model.
- Sorrento and its collaboration partner, Dyadic International, Inc., are working together to complete the IND-enabling studies for IND submission for human vaccination trials globally.
- A MultiValent RBD-based vaccine utilizing the RBDs from SARS-CoV-2 and its major VoCs is in development to potentially serve as a universal vaccine and potentially as a universal booster for other COVID-19 vaccines.
The generation of a protein-based vaccination candidate that provides protection against the original SARS-CoV-2 virus and emerging VoCs has proved to be challenging. The publication reports the protective neutralizing activities of the sera of vaccinated animals against a broad spectrum of SARS-CoV-2 virus and its major VoCs by immunization with recombinant Spike protein receptor binding domain (RBD) administered in conjunction with aluminum-phosphate adjuvant intramuscularly. Immunizing mice with RBD protein vaccine with simple aluminum-phosphate adjuvant led to the production of IgG antibodies recognizing the Spike protein of the prototype SARS-CoV-2 as well as the VoCs, such as Alpha (“United Kingdom”), Beta (“South Africa”), Gamma (“Brazil/Japan”), and Delta (“India”). RBD protein immunization induced to the activation of a Th1 polarization of CD4 positive T cells. Furthermore, RBD protein immunization produced IgG antibodies in vivo, which exerted high neutralizing activity against live SARS-CoV-2 and the highly transmissible VoCs, Beta and Delta, as well as Gamma to a lesser extent. Thus, DYAI-100 represents a promising COVID-19 vaccination candidate against COVID-19 that may potentially offer broad protective range against emerging VOCs of SARS-CoV-2 virus.
Sorrento is a clinical stage, antibody-centric, biopharmaceutical company developing new therapies to treat cancers and COVID-19. Sorrento's multimodal, multipronged approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as fully human antibodies (“G-MAB™ library”), clinical stage immuno-cellular therapies (“CAR-T”, “DAR-T™”), antibody-drug conjugates (“ADCs”), and clinical stage oncolytic virus (“Seprehvir™”). Sorrento is also developing potential antiviral therapies and vaccines against coronaviruses, including COVIGUARD™, COVI-AMG™, COVISHIELD™, Gene-MAb™, COVI-MSC™ and COVIDROPS™; and diagnostic test solutions, including COVITRACK™, COVISTIX™ and COVITRACE™.
Sorrento's commitment to life-enhancing therapies for patients is also demonstrated by our effort to advance a first-in-class (TRPV1 agonist) non-opioid pain management small molecule, resiniferatoxin (“RTX”), and SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (SEMDEXA™), a novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, and to commercialize ZTlido® (lidocaine topical system) 1.8% for the treatment of post-herpetic neuralgia. RTX has completed a Phase IB trial for intractable pain associated with cancer and a Phase 1B trial in osteoarthritis patients. SEMDEXA is in a pivotal Phase 3 trial for the treatment of lumbosacral radicular pain, or sciatica. ZTlido® was approved by the FDA on
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Source: Sorrento Therapeutics, Inc.